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New imaging technique could help pick embryos for IVF

Anna Leida

Progress Educational Trust

13 September 2017

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[BioNews, London]

A new imaging technique can help assess the quality of early-stage embryos.

Termed hyperspectral imaging, the technique could one day improve IVF success rates by providing an objective assessment of embryo health, which currently depends on the opinion and experience of the clinician.

'Preimplantation genetic screening of embryos generally takes place under a normal optical microscope,' said lead author Dr Melanie Sutton-McDowall of the University of Adelaide, Australia. 'Although it's quite easy to discern poor embryos (due to differences in uniformity), it is far harder for the clinician to determine objectively, the viability of the other embryos.'

Developed by researchers at the ARC Centre of Excellence for Nanoscale BioPhotonics at the University of Adelaide, the imaging technique is able to identify variations in metabolic activity in cultivated embryos. Metabolic activity is considered one of the most important factors to determine embryo health, and embryos with a homogenous metabolic profile are typically the most healthy.

In this study, published in Human Reproduction, the scientists could detect metabolic differences between five-day-old cow embryos exposed to two different oxygen concentrations (20 percent and 7 percent) using hyper spectral imaging, in contrast to traditional fluorescence microscopic techniques. Each set of embryos subsequently showed different levels of developmental success.

Current techniques can measure the light (fluorescence) naturally produced by cells during chemical reactions, but hyperspectral imaging can measure light intensity across a range of wavelengths. This means it can capture information from several processes simultaneously.

While the use of hyperspectral imaging in IVF clinics and for human embryos is some years away, Dr Sutton-McDowall expects to see the technology adapted for use fairly quickly.

'I think we’ll see this innovative approach commercialized fairly quickly,' she predicted. 'IVF is a costly and complex treatment. Any new method that can help improve the odds of women successfully having babies is of benefit to both clinicians and their patients.'

Various kinds of microscopic systems are already used to provide non-invasive, time-lapse information of growing embryos in the IVF clinic.


Hyperspectral imaging could boost IVF success

Optics.org | 29 August 2017

Hyperspectral microscopy can detect metabolic heterogeneity within bovine post-compaction embryos incubated under two oxygen concentrations (7% versus 20%)

Human Reproduction | 28 August 2017

New technique to aid IVF embryo selection

University of Adelaide | 29 August 2017

University of Adelaide IVF breakthrough helps find healthy embryos by non-invasive process

The Advertiser | 29 August 2017



© Copyright Progress Educational Trust

Reproduced with permission from BioNews, an email and online sources of news, information and comment on assisted reproduction and genetics.

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Date Added: 13 September 2017   Date Updated: 13 September 2017
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