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Advancing the ART of Human Reproduction: Physiology and Technology

Carole Chisholm

Serono Symposia International, Inc.

08 April 2005

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Technological innovations and advances in genetics will enhance the ability to both evaluate and improve embryonic competence. This 3-day, in depth course will review what is known about the basic reproductive processes that represent rate-limiting steps in human reproduction. The participant will understand the full spectrum of these limits, starting by reviewing clinical data and extending fully through the molecular level. Methodologies currently being used to evaluate embryonic competence will be reviewed including technical requirements, biologic material, equipment, and personnel. Future technologies and screening strategies will then be presented, such that clinical reproductive endocrinologists, embryologists, and scientists will have a full understanding of the technologies as they become clinically available in the next several years. The course will provide opportunities to interact with expert faculty. In addition, two adjunct hands-on workshops in blastomere preparation for PGD are being offered.


Reproductive endocrinologists, embryologists, basic scientists, and other related health professionals will benefit from this course.


At the conclusion of this program, the participant should be able to:

- Understand the genetic basis of human embryonic competence;

- Explain how epigenetic factors affect human development;

- Understand endometrial and oocyte determinants of implantation;

- Appreciate the limitations and promise of new technologies in IVF.


Richard T. Scott, M.D., Scientific Chair

Reproductive Medicine Associates of New Jersey

Morristown, New Jersey, USA

Michael M. Alper, M.D.

Boston IVF and

Harvard Medical School

Waltham, Massachusetts, USA


Serono Symposia International, Inc.

1099 Hingham Street

Rockland, MA 02370 USA

Telephone 800-283-8088 or 781-681-2352

Fax: 781-681-2915



An adjunct hands-on workshop session will be offered on Friday, May 13, 2005 from 5:30 pm to 9:30 pm. A second, concurrent, hands-on workshop session will be offered on Saturday, May 14, 2005 from 12:30 pm to 4:30 pm. Each workshop session is limited to 16 participants. The didactic portion of the workshop will address the theory and practice of preimplantation genetics in the IVF setting. The majority of the workshop will be spent in hands-on training in polar body, blastomere, and trophectoderm biopsy, cell spreading, and fixation techniques. Course participants will be acquainted with current equipment such as microscopes, micromanipulation equipment and laser system to incorporate biopsy and fixation techniques immediately into their IVF program. All work will be closely supervised by expert faculty. Workshop attendees will be provided with an additional syllabus with protocols and technical materials and either dinner (Friday) or lunch (Saturday), and refreshments. Microdissection equipment, display capability, and biopsy and fixation microscopes will be generously supplied by MidAtlantic Diagnostics, Inc.


Thursday, May 12, 2005

Plenary Session

Richard Scott, Session Chair

3:00 ? Registration

4:00 pm

4:00 pm Introductory Remarks

Richard Scott, Scientific Chair

4:15 pm Welcome Address

The Future of ART: What Are Our Most Critical Technologies and Issues?

Paul McDonough

5:15 pm Embryo Research: The Legal, Ethical, and

Regulatory Limitations

Alta Charo

6:00 pm ART and Multiple Gestation: Have We

Succeeded or Failed?


6:45 pm Welcome Reception

Friday, May 13, 2005

7:00 am Continental Breakfast (provided)

Session I ? Reproductive Competence

Gary Smith, Session Chair

8:00 am The Spin from Spindle Abnormalities and Meiotic Errors

David Keefe

8:45 am Is There More to Male Reproductive

Competence Than Fertilization?

Kathy Miller

9:30 am Embryo Fingerprinting: A Prospect for Embryo


Richard Scott

10:15 am Break

Session II ? Laboratory Evaluation of Reproductive Competence

Douglas Powers, Session Chair

10:30 am Embryonic Development: An Awakening of Gene


Douglas Powers

11:15 am PGD: The Good, The Bad, and The Ugly

Richard Scott

11:45 am Embryo Morphology: More Than Meets the Eye?

Marlena Duke

12:30 pm Lunch

Session III ? Evolving Technologies in ART

Jason Barrit, Session Chair

2:00 pm In Vitro Maturation: Is It Mature Yet?

Gary Smith

2:45 pm Microfluidics: A New Biomedical Engineering Technique for ART

Gary Smith

3:30 pm Break

3:45 pm Oocyte Cryopreservation: Technologies, Safety, and Applications

Tom Toth

4:30 -

5:15 pm Ovarian Tissue Preservation: Challenges for the Future

Jacques Donnez


5:30 ?

9:30 pm Blastomere Preparation for PGD

Hands-on Workshop

Saturday, May 14, 2005

7:00 am Continental Breakfast (provided)

Session IV ? Offspring from ART

Michael Alper, Session Chair

8:00 am Epigenetics: What the Genome Never Told Us


8:45am Imprinting Disorders in ART: Risk or Association?

James Toner

9:30 am Nuclear Transfer: Promise for the Future or

More Smoke and Mirrors?

Jason Barrit

10:15 am Break

10:30 am Can We Demonstrate that an Embryo is


Marcelle Cedars

11:15 am Embryo Donation: What Are the Stumbling Blocks?

David Keefe

12:00 pm Lunch


12:30 ?

4:30 pm Blastomere Preparation for PGD

Concurrent Hands-on Workshop

Session V ? Evaluating and Managing Endometrial Sufficiency

James Toner, Session Chair

1:30 am Assessing Implantation Potential

Richard Paulson

2:15 pm Non-Traditional Markers of Endometrial

Receptivity: Are They Ready For the Clinic?

Bruce Lessey

3:00 pm Break

3:15 pm Progesterone and ART: Fact and Fiction

James Toner

4:00 -

4:45 pm Beyond the HSG: New Imaging Technologies for

the Fertility Specialist

Elizabeth Puscheck

Sunday, May 15, 2005

7:00 am Continental Breakfast (provided)

Session VI ? Contemporary Issues in Follicular Stimulation

Richard Scott, Session Chair

8:00 am GnRH Antagonists: Are Outcomes Impacted?

Alan Copperman

8:45 am LH: Is There a Threshold and a Ceiling?

Zeev Shoham

9:30 am Break

Session VII ? Adjuncts for ART

Michael Alper, Session Chair

9:45 am How Can We Really Optimize IVF Outcomes?

Michael Alper

10:30 am Impact of Mental Health on ART Outcome: Strategies for Intervention

Alice Domar

11:15 am Acupuncture: The Yin and Yang for IVF

Michael Graubert

12:00 pm Closing Remarks

Michael Alper


This program is supported in part by an unrestricted educational grant from Serono, Inc.

All Serono Symposia International, Inc., programs are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of Serono Symposia International, Inc.


Advancing the ART of Human Reproduction

May 12- 15, 2005

(Please type or print clearly)


Last Name First Name M.I. Degree








City Province/State/Country Postal Code/Zip


Office Telephone Fax Number


E-Mail Address (Please print clearly)

____Advanced Full Registration US $550, prior to or on April 21, 2005

____ Full Registration US $650, after April 21, 2005

____ Advanced Trainee/Fellow Registration US $450*, prior to or on April 21, 2005

*Must be accompanied by a letter certifying status.

____ Trainee/Fellow Registration US $550*, after April 21, 2005

*Must be accompanied by a letter certifying status.

____ Guest Fee US $100**

**Guest includes friends and family members who accompany a full meeting registrant. Guests may attend all meals and social functions.


Guest Name (Last, First)



____ Friday, May 13, 2005 US $150.

Workshop limited to first 16 participants. Dinner provided.

____ Saturday, May 14, 2005 US $150. Concurrent session.

Workshop limited to first 16 participants. Lunch provided.

____ Payment by check or money order

Payable to: Serono Symposia International, Inc.

Charge to the following Credit Card:

___ MasterCard ___ Visa ___ American Express


Card Number Exp. Date

If you require special assistance (wheelchair, auxiliary aids) or special dietary requirements, please indicate and we will contact you. ___ Yes

Mail or Fax to: Registrar: Advancing the ART

Serono Symposia International, Inc.

1099 Hingham Street

Rockland, MA 02370 USA

FAX 781-681-2915

Or you can register online at www.seronosymposia.org


Jason A. Barrit, Ph.D.

Reproductive Medicine Associates of New York

New York, New York, USA

Marcelle I. Cedars, M.D.

UCSF Women?s Health

Reproductive Endocrinology and Fertility

San Francisco, California, USA

R. Alta Charo, Ph.D.

University of Wisconsin Law School and

Department of Medical History and Bioethics

University of Wisconsin Medical School

Madison, Wisconsin, USA

Alan Copperman, M.D.

Reproductive Medicine Associates of New York

New York, New York, USA

Alice D. Domar, Ph.D.

Mind/Body Center for Women?s Health

Boston IVF

Waltham, Massachusetts, USA

Jacques Donnez, M.D., Ph.D.

Cliniques Universitaires Saint-Luc and

Catholic University of Louvain

Brussels, Belgium

Marlena Duke, MSc

Reproductive Medicine Associates of New York

New York, New York, USA

Michael D. Graubert, M.D.

Palmetto Fertility Center of South Florida

Miami, Florida, USA

David L.Keefe, M.D.

Division of Reproductive Medicine and Infertility

Women and Infants Hospital

Providence, Rhode Island, USA


Tufts - New England Medical Center

Division of Reproductive Medicine and Infertility

Department of Obstetrics and Gynecology

Boston, Massachusetts, USA

Bruce Lessey, Ph.D., M.D.

Department of Obstetrics and Gynecology

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, USA

Paul G. McDonough, M.D.

Medical College of Georgia

Department of Obstetrics and Gynecology

Augusta, Georgia, USA

Kathleen Miller, BCTS

Reproductive Medicine Associates of New Jersey

Morristown, New Jersey, USA

Richard J. Paulson, M.D.

Reproductive Endocrinology and Infertility Division

University of Southern California School of Medicine and

University of Southern California Infertility Center

Los Angeles, California, USA

R. Douglas Powers, Ph.D.

Boston IVF

Waltham, Massachusetts, USA, and

Boston College, and

Harvard Medical School

Boston, Massachusetts, USA

Elizabeth Puscheck, M.D.

Department of Obstetrics and Gynecology

Division of Reproductive Endocrinology and Infertility

Wayne State University School of Medicine

Detroit, Michigan, USA

Zeev Shoham (Schwart), M.D.

Reproductive Medicine and Infertility Unit

Kaplan Hospital

Rehovot, Israel

Gary D. Smith, Ph.D.

Department of Obstetrics and Gynecology

Reproductive Endocrinology and Infertility Division Assisted Reproductive Technologies Laboratory

University of Michigan Health System

Ann Arbor, Michigan, USA

James Toner, M.D., Ph.D.

Atlanta Center for Reproductive Medicine

Woodstock, Georgia, USA

Thomas L. Toth, M.D.

Vincent Memorial in Vitro Fertilization Unit

Massachusetts General Hospital

Boston, Massachusetts, USA


Physician: Serono Symposia International, Inc., is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

Serono Symposia International, Inc., designates this educational activity for a maximum of 20.5 category I credits towards the AMA Physician?s Recognition Award. Four (4) additional category I credits may be claimed for workshop attendance. Each physician should claim only those credits that he/she actually spent in the educational activity.

Laboratory Professional: Application will be made to the American Board of Bioanalysis (ABB) for Professional Enrichment Education Renewal (PEER) contact hours.


The official language of the Symposium is English.


The registration fee for Advancing the ART is US $550 on or before April 21, 2005 and US $650 after April 21, 2005 for a full registration. The registration fee is US $450 on or before April 21, 2005 and US $550 after April 21, 2005 for trainees, students, and fellows. This fee includes: all plenary sessions, three continental breakfasts, two lunches, one reception, refreshments, and course book.



The registration fee for the hands-on workshop offered Friday, May 13, 2005 is US $150. The registration fee for the concurrent hands-on workshop offered Saturday, May 14, 2005 is US $150. This fee includes: one dinner (Friday) or lunch (Saturday), refreshments, and course materials. The workshop curricula are identical. Attendance at each workshop is limited to the first 16 participants.

Payments may be made by check, money order, American Express, MasterCard, or Visa. All completed registrations will be acknowledged by mail. Cancellations will be assessed a US $50 administrative fee and must be received no later than May 1, 2005.


Loews Miami Beach Hotel

1601 Collins Avenue

Miami Beach, Florida


Tel: 305-604-1601



Situated in the heart of the culturally diverse and fabulously hip art deco section of South Beach, the Loews Miami Beach Hotel offers innovative cuisine, efficient, friendly service and an elegant setting. Combined with sunshine, ocean breezes and a pristine beach, the hotel amenities include an oceanfront pool, private beach, in room internet access and a fitness center.

A limited block of rooms has been reserved for this meeting at a special rate of $229/night (single/double, USD) plus applicable tax, which is currently 13%. For reservations, telephone the hotel directly at Tel: 800-235-6397. We recommend that you register at the hotel early to secure a room. Reservations made after

April 21, 2005 are on a space-available basis.


We are pleased to offer discounted fares to our attendees through our air partner American Airlines. For your convenience, you may book these fares through your travel agent, or by calling our travel agent BTI/World Travel at 800-637-7872, or through American Airlines directly at 800-221-2255. Please be sure to mention the Meeting Index #17667 to take advantage of these low fares.

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Date Added: 08 April 2005   Date Updated: 08 April 2005
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