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Webinar: ETHICAL CONSIDERATIONS AND MANAGEMENT OF CRYOSTORAGE SAMPLES

International IVF Initiative 19 March 2024
ETHICAL CONSIDERATIONS AND MANAGEMENT OF CRYOSTORAGE SAMPLES

3pm EDT/ 7pm UK/ 8pm CET, Tuesday 26th March 2024.
NOTE TIME

Moderators:
James Lawford Davies and Dr. Christine Allen

Panelist: Adam B. Wolf

Presenting:
Frozen assets: embryo disputes and posthumous us-James Lawford Davies

Life after death: ethics of postmortem reproduction- Prof. Guido Pennings

Unclaimed embryo and gamete storage- John Whitney
A talk kindly sponsored by CooperSurgical®

Q and A

 

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News: Unlocking New Frontiers in Reproductive Biology: Turning Diploid Somatic Cells into Haploid Cells

IVF.net Newsdesk 19 March 2024

In a groundbreaking study published in Science Advances on March 8, 2024, a team led by Aleksei Mikhalchenko, Nuria Marti Gutierrez, and Shoukhrat Mitalipov unveiled a novel approach that could revolutionize the field of reproductive biology. Their research introduces a method for inducing haploidy in somatic cells, paving the way for innovative in vitro gametogenesis (IVG) techniques.

The Essence of the Discovery

The research team developed a technique that initiates premature cell division by transferring nuclei from diploid somatic cells, specifically those in the G0/G1 phase, into the cytoplasm of metaphase mouse oocytes. This procedure bypasses the need for DNA replication, leading to the formation of haploid daughter cells. What's remarkable is the study's demonstration of accurate segregation of homologous chromosomes, resulting in complete haploid genomes. This process appears more efficient in cells from inbred strains compared to hybrids, suggesting a crucial role for genetic homology.

Why It Matters

Haploid cells, containing a single set of chromosomes, are a cornerstone of sexual reproduction and genetic diversity. The traditional path to producing haploid gametes from diploid cells involves inducing meiosis—a complex and tightly regulated process. The ability to convert diploid somatic cells directly into haploid cells outside of the traditional meiotic pathway opens new doors for reproductive technology and research, offering hope for advancements in fertility treatments and the study of genetics.

Behind the Scenes

To achieve their findings, the researchers conducted meticulous experiments involving the collection of mature mouse oocytes and cumulus cells. Through somatic cell nuclear transfer (SCNT), they introduced somatic cell nuclei into oocytes devoid of their original DNA. This setup led to the unexpected yet precise segregation of chromosomes, akin to what occurs during the first division of meiosis, but without the genetic recombination typically seen in meiosis.

The Bigger Picture

This study not only highlights a novel method for haploidization but also emphasizes the importance of genetic homology in successful chromosome segregation. The findings could have significant implications for the field of IVG, providing a new strategy for generating gametes from somatic cells. This could be particularly beneficial for individuals facing fertility challenges, offering them new hope.

Moreover, the research sheds light on the mechanisms of chromosome segregation and pairing, contributing valuable insights to our understanding of cellular biology. The ability to induce haploidy in somatic cells could also facilitate genetic research, enabling scientists to study gene function and inheritance patterns more efficiently.

Looking Ahead

While the study marks a significant leap forward, the researchers acknowledge that further investigation is needed to fully understand the mechanisms behind this process and its potential applications. The findings open up exciting possibilities for reproductive biology and medicine, promising to fuel future research and innovations in the field.

This breakthrough is a testament to the power of scientific inquiry and innovation, offering a glimpse into the future of reproductive biology and genetic research. As we continue to explore the potential of this technique, we may find ourselves on the cusp of a new era in IVG and beyond.

Sources

Science Advances- Induction of somatic cell haploidy by premature cell division

https://www.science.org/doi/10.1126/sciadv.adk9001


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News: Alabama Governor Enacts Law to Safeguard IVF Services

IVF.net Newsdesk 11 March 2024

In a decisive move, Alabama Governor Kay Ivey has officially enacted legislation that offers legal protection to in vitro fertilization (IVF) providers. This development comes in the wake of a controversial court decision that classified frozen embryos similarly to children, sparking widespread concern among fertility clinics regarding potential legal repercussions.

The urgency to reinstate IVF services was palpable, prompting the Governor to swiftly sign the bill into law. This action was in direct response to the temporary cessation of services at several leading fertility clinics in the state, following a ruling by the Alabama Supreme Court. The court had allowed three couples to file wrongful death lawsuits after their frozen embryos were accidentally destroyed, treating the embryos as "extrauterine children" under wrongful death statutes.

This legislation, effective immediately, ensures that IVF providers are safeguarded against both criminal prosecution and civil lawsuits related to embryo damage or death during the IVF process. However, it does allow for civil suits against IVF product manufacturers, with compensation limited to the cost of the affected IVF cycle.

The bill's passage was a relief for many, including medical professionals and potential parents, who had voiced their concerns and urged lawmakers for a resolution. Clinics like Alabama Fertility have announced plans to resume embryo transfers immediately, signaling a return to normal operations and the hope for many families to grow.

Despite the protective measures for providers, the bill has faced criticism for not directly addressing the legal status of embryos created in IVF labs, a topic that remains contentious. The law sidesteps the broader issue of embryo personhood and focuses instead on enabling IVF services to continue without legal hindrance.

Critics, including Republican Senator Larry Stutts, argue that the legislation prioritizes provider protection over patient rights, raising ethical and legal questions about the valuation of human life. Meanwhile, proposals by House Democrats to clarify the legal definition of embryos were not considered, highlighting the political and moral complexities surrounding IVF and reproductive rights.

The legislation represents a temporary fix to a pressing issue, with the potential for further legislative action as the state grapples with the implications of its strict anti-abortion stance and the definition of life. The debate continues, underscoring the delicate balance between advancing reproductive technologies and navigating the ethical landscape they inhabit.

Sources:

AP News - Alabama governor signs legislation protecting IVF providers from legal liability into law

 


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Course: Embryology and IVF

Dr. D'Pankar Banerji 05 March 2024
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Conference: 25th Royan International Congress

Royan Institute 04 March 2024
25th Royan International Congress

Scientific Secretary of the 25th International Reproduction Congress is Dr. Maryam Hafezi, the Scientific Secretary of the 20th Stem Cell Congress is Dr. Leila Taghiyar, the Scientific Secretary of the Nursing and Midwifery Seminar is Mrs. Zahra Hessari, and the Executive Secretary of the Congress is Dr. Ruhollah Fathi.
The two international congresses will be held in English and the Nursing and Midwifery seminar will be held in Persian. You can visit the congress website for detailed information on topics and guidelines.
Those who are interested can submit their scientific abstracts through the website of Royan International Congress at the address www:royancongress.com until May 05,2024. After the final judging of the abstracts, the selected titles will be announced by July 05, 2024.


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Announcement: Admission Open 2024 for MSc ( Clinical Embryology & Pre Implantation Genetics)

Asia Pacific Institute of Embryology 04 March 2024
Admission Open 2024 for MSc ( Clinical Embryology & Pre Implantation Genetics)

Eligibility Criteria 

•    B.Sc (Science) 
•     MBBS
•     BDS
•     BAMS
•     BHMS
•     Pharmacy
•    Any other equivalent degree

 •    B.Sc Nursing 
•    BVSc 
•    Dairy
•    Fishery 
•    Engineering with Science (Biotechnology and Life science related)

For application form and prospectus
Email: [email protected]                                                                                                                  Website : www.embryologytraining.com                                                                                                             Contact: 9108849758 


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Announcement: MSc Clinical Embryology

Liverpool John Moores University 02 March 2024


The MSc Clinical Embryology program at Liverpool John Moores University, in collaboration with CARE Fertility, is designed for those aiming for a career in fertility treatment and reproductive research. This unique course combines academic and practical experiences, offering state-of-the-art lab training in IVF technologies and a deep understanding of fertility research advancements. Graduates will be well-prepared for the fertility treatment job market but should note that the program does not lead to Clinical Scientist registration. For more detailed information, please visit the course page.


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News: Alabama Legislature Advances Bills to Safeguard IVF Services

IVF.net Newsdesk 02 March 2024

In a decisive move, the Alabama Legislature, comprising both the Senate and the House, has approved measures designed to secure in vitro fertilization (IVF) treatments. This legislative action comes in the wake of a significant ruling by the state Supreme Court, which categorized embryos as children, thereby placing IVF procedures at risk of legal complications.

The approved bills, heralded by Republican lawmakers, aim to specifically safeguard IVF patients and medical professionals from potential legal actions. This step is crucial for resuming the operations of IVF clinics that were forced to suspend services following the court's decision.

Key Provisions and Legislative Journey

The Senate passed bill SB 159, offering civil and criminal immunity to individuals and entities involved in IVF services from any lawsuits related to the damage or death of an embryo. A similar bill, HB 237, received approval in the House, mirroring the Senate's intentions.

Despite extensive debates that spanned nearly six hours and saw objections from various quarters, the bills received overwhelming support. However, concerns were raised by both Democrats and Republicans. Democrats pointed out the lack of clarity on whether an IVF-created embryo should be legally considered a child, a core issue stemming from the Supreme Court's verdict. On the other hand, some argued that the proposed immunity might be overly broad, potentially leaving women without legal recourse in cases of adverse effects during IVF treatments.

The Path Forward

Republican sponsors of the bills have admitted to the imperfections in their proposals but emphasized their necessity as an interim solution to allow the reopening of IVF clinics. This legislative action underscores a pressing need to address the complications introduced by the Supreme Court's ruling and reflects a commitment to revisiting and refining the legal framework surrounding IVF.

Reactions and Broader Implications

The proposed bills have been met with criticism from reproductive rights advocates, who argue that they fall short of comprehensively safeguarding IVF care against the implications of the recent court decision. Critics, including Planned Parenthood Southeast, highlight the limited scope of these measures in fully addressing the challenges posed by the ruling, which has sparked a nationwide debate on reproductive rights and IVF practices.

As Alabama lawmakers work towards a unified version of the bill to present to Governor Kay Ivey for her signature, the broader conversation around IVF and reproductive rights continues to evolve. This legislative effort represents a crucial step in ensuring the availability and safety of IVF treatments in Alabama, amidst ongoing discussions on the legal and ethical considerations of reproductive technologies.

 

Source

NBC News - Alabama Senate and House pass bills to protect IVF after court ruling


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News: ART & Embryology training program

Chennai Fertility Center and Research Institute 01 March 2024
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Webinar: RBMO LIVE 7

International IVF Initiative 21 February 2024
RBMO LIVE 7

3pm EST/ 7pmUK/ 8pm CET, Tuesday 12th March 2024.
NOTE TIME

Hot Topics and Editors’ Choices

Moderators:
Prof. Juan A Garcia-Velasco and Prof. Nick Macklon

Presenters:
“Effect of ejaculatory abstinence period on fertilisation and clinical outcomes in ICSI cycles: a retrospective analysis of 6,919 cycles” - Ms Greta Cermisoni

“Oocyte rescue: in vitro maturation does not adversely affect chromosome segregation during the first meiotic division" - Dr. Marga Esbert

"Publishing Pro Tips: Submitting your manuscripts" - Duncan Nicholas, Development Editor RBMO 

Q and A

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