Tuesday 1 September, 2020. 8PM GMT / 9PM CET / 3PM EST
Moderators: Kimball Pomeroy, PhD and Dawn Kelk, PhD
"Cryostorage of Reproductive Tissues in the IVF Laboratory: ASRM Committee Opinion"
Sangita Jindal, PhD, HCLD
Summary: Catastrophic tank failures in recent years have reinforced the importance of cryogenic management in our embryo production laboratories. Based upon scientific principles and laboratory experience, best practices/minimal standards for safe and reliable storage of cryopreserved reproductive tissue have been proposed. Considering the emphasis in embryo vitrification and fertility preservation in the field of Reproductive Medicine, our goals are to optimize cryo-viability and effectively mitigate and eliminate embryo/gamete risks associated with cryopreservation and cryostorage.
"Cryopreservation and IVF in the Time of Covid-19: What is the Best Good Tissue Practice (GTP)?"
Mitchel C. Schiewe, MS, PhD, HCLD
Unknown risks relating to the SARS-CoV-2 virus and sperm, ova and embryos necessitate a reexamining of how human IVF is performed. Over the last decade improvements in cryosurvival and live birth outcomes have been associated with zona pellucida breaching procedures (e.g., blastocyst collapsing and biopsying). In turn, today embryos are generally no longer protected by an intact zona pellucida when vitrified and in cryostorage. Additionally, high security storage containers have proven to be resilient to potential cross-contamination and reliable for routine human sperm freezing and embryo vitrification.
Several options to current IVF practices are presented that can effectively mitigate the risks of cross-contamination and infection due to the current Covid-19 pandemic or other viral exposures. The question remains, is heightened security and change warranted where the risks of disease transmission likely remains negligible.
Organized by the SRBT
Purpose: To report the utilization of diagnostic intracytoplasmic sperm injection (D-ICSI), an ICSI cycle performed in the natural cycle, to obtain information about embryo development potential after sperm injection into zona pellucida (ZP)-free oocytes. Materials and Methods: We report the case of a couple with primary unexplained infertility with a history of previous failed, in vitro fertilization intracytoplasmic sperm injection (IVF-ICSI) cycles characterized by the presence of ZP-free oocytes. Whole exome sequencing (WES) was carried out to analyse the possible genetic basis of oocyte abnormality. Results: Diagnostic ICSI provided information about the embryo development potential from ZP-free oocytes and allowed better planning of the subsequent ICSI cycle. WES revealed that the absence of ZP was likely to be due to a new (ZP1) mutation. The subsequent ICSI cycle resulted in the delivery of a healthy baby. Discussion: To the best of our knowledge, our report is the first to describe the use of D-ICSI to determine the feasibility of embryo development and implantation in a patient with ZP1 mutation, resulting in the subsequent delivery of a healthy baby. We used ‘diagnostic’ ICSI in the normal menstrual cycle to explore the feasibility of embryo development after sperm injection into ZP-free oocytes. Our results may expand the spectrum of diagnostic procedures associated with unexplained infertility.
8 weeks certified online digital course with extensive contact program for two days - First time in India Clinical & Embryology Academy of ART by i-Ceat
Online i-Courses Available
Course Name : Basic and advanced clinical andrology, IUI, reproductive ultrasound and QA/QC
✔️E-learning
✔️Online lectures
✔️Digital learning modules
✔️Recorded video lectures series
✔️Online exams
✔️Extensive Hands-on 2 days course
Course include :
✔️Setting up of an andrology and IUI lab
✔️Semen analysis
✔️Tips tricks
✔️Microfluidics
✔️Sperm function tests
✔️Sperm processing techniques
✔️Basic of USG, follicular monitoring, 3D/4D/CD, SSG
To learn more visit: <http://i-ceat.com/>
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We are pleased to invite you to a Live Zoom Session with Dr. Alan Trounson on 29th August 2020 at 4:00 PM (IST), 12:30 PM (Stockholm),11:30 AM (London), 02:30 PM (Dubai), 8:30 PM (Melbourne), 6:30 AM (New York), 6:30 PM (Singapore)
Limited Seats only!! Hurry Up and Grab your seat!!!
Course Name : Basic to Advanced embryology for Clinicians & Embryologist - Embryo Culture, ICSI, Cryobiology & QA/QC
First time in India - Digital and hands on training courses in IVF and IUI at Clinical & Embryology Academy of ART (i-Ceat), New Delhi.
To learn more visit : <http://i-ceat.com/>
WhatsApp @ https://wa.me/918375994957
Or Email: [email protected]
Tuesday 25 August, 2020. 8PM GMT / 9PM CET / 3PM EST
Moderators: Colin Howles & Giles Palmer
Implantation - the Final Challenge in a Complex Treatment Process
Dr. Juan Garcia Velasco
Zooming in on the Most Fantastic Voyage
Dr. Yorgos Nikas
Is the Endometrium the New Embryo?
Professor Nick Macklon
Organized by the International IVF Initiative
Limited Seats only!! Hurry Up and Grab your seat!!!
First time in India - Digital and hands on training courses in IVF and IUI at Clinical & Embryology Academy of ART (i-Ceat), New Delhi.
Course Name : Basic to Advanced embryology for Clinicians & Embryologist - Embryo Culture, ICSI, Cryobiology & QA/QC
Starting From 12th Oct, 2020
To learn more visit : <http://i-ceat.com/>
WhatsApp @ https://wa.me/918287883005
Or Email: [email protected]
Tuesday 18 August, 2020. 8PM GMT / 9PM CET / 3PM EST
Moderators: Dr. Alison Bartolucci & Dr. Zsolt Peter Nagy
Principles of Cryopreservation and Optimization of Vitrification
Dr. Jeremy Chang
The state of ART in vitrification: the best technical approaches and outcomes
Dr. Ana Cobo
Health of offspring following "frozen" embryo transfer
Professor Anja Pinborg
Organized by the International IVF Initiative
Our goal in writing this guideline article was to summarize the rapid advancements in SDF measurement and propose specific clinical indications in an evidence-based approach. Subsequently, the literature on SDF testing, including etiologies, risk factors, laboratory assays, implications on reproductive outcomes and appropriate clinical management has expanded dramatically.
Trigger of ovulation is one of the corner stones of reproductive medicine. For the last several decades estradiol held a firm position as a hormone at the upstream of the GnRH pathway that culminates in the release of gonadotropins that cause a follicle to rupture. Progesterone also looked like a promising candidate, but there were two major obstacles to accepting this possibility. The first one is its well known property to block ovulation, which makes it a main component of every birth control pill. The second obstacle was even more formidable: it was convincingly shown that estradiol can trigger ovulatory gonadotropins (LH and FSH) surge in castrated females, who are completely lacking ovaries and therefore have no endogenous ovarian progesterone. Our work for the first time resolves both of those roadblocks on a path of recognizing progesterone's ability to trigger ovulation and proposes a new ovulation paradigm.
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