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News: THE FUTURE OF FREEZING PART 1

International IVF Initiative 21 February 2024
THE FUTURE OF FREEZING PART 1

3pm EST/ 8pmUK/ 9pm CET, Tuesday 5th March 2024.

This webinar is kindly sponsored by Future Fertility

Moderators:
Ms. Jullin Fjeldstad and Dr. Dan Nayot


Presenters:
Fast and Furious: New strategies in oocyte and embryo vitrification and warming- Dr. Juergen Liebermann

Long-term preservation of germ cells and gonadal tissues at ambient temperatures- Dr. Pierre Comizzoli

Techniques of Cryopreservation for Ovarian Tissue and Whole Ovary: vitrification vs slow-Dr. Amir Ara

Q and A

VIEW HERE


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I3 Revisited: 24hr QC

International IVF Initiative 21 February 2024

A presention on the imporance of QC and redundancy in IVF by Dr. Jean M. Popwell of Inception Fertility.

Including the latest in Monitoring with Thermographic Technology


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News: Alabama's Frozen Embryo Verdict Ignites Concern Among Patients and Physicians

IVF.net Newsdesk 21 February 2024

In an unprecedented ruling, the Alabama state supreme court has classified frozen embryos as "extrauterine children," generating a wave of uncertainty and concern among individuals seeking or providing in vitro fertilization (IVF) treatments. This decision has cast a shadow of confusion and apprehension over IVF practitioners and their patients, as they grapple with the ramifications of this landmark verdict.

Patients at the Alabama Fertility clinic, where Dr. Mamie McLean practices, are inundated with concerns about the future of their parenthood dreams. They are eager to make informed decisions about their frozen embryos without the supreme court's intervention. Dr. McLean, amidst this turmoil, admits the lack of clear guidance has left them uncertain about how to proceed with patient care. The ruling challenges the legality of standard IVF procedures, including the freezing, thawing, and transferring of embryos, raising questions about the disposal of unused embryos.

The IVF community fears this could signal the end of IVF practices in Alabama, as the legal risks may drive providers and patients to seek services elsewhere. Sean Tipton, from the American Society for Reproductive Medicine, criticizes the ruling for its lack of consideration for the real-world impacts, which he describes as profound and potentially devastating.

The process of IVF, which involves stimulating egg production, fertilizing eggs in a lab, and possibly freezing embryos for future use, is now fraught with legal risks. The possibility of being legally penalized for the natural failure of an embryo during the freezing and thawing process has raised alarms. Experts are concerned that this may lead to the necessity of transferring all created embryos, increasing the risks of multiple pregnancies and associated health complications.

The already high maternal mortality rates in the United States, particularly among Black women, could be exacerbated by this ruling. With Alabama's maternal health outcomes among the worst in the nation, the implications of the supreme court's decision are particularly alarming.

IVF procedures, including the crucial step of testing embryos for abnormalities, are now in jeopardy. This could lead to significant ethical and medical dilemmas for patients and providers alike. The state's stance on abortion further complicates decisions for pregnancies with significant abnormalities.

Despite the confusion, Dr. McLean and her colleague Dr. Michael C Allemand continue to offer IVF services while awaiting legal guidance. The desire to provide patients with the opportunity to have genetically related children remains strong, despite the potential need to relocate practices out of state.

This ruling reflects a broader trend of granting embryos and fetuses legal rights, often driven by anti-abortion advocacy. It marks a significant challenge to IVF, a concern long anticipated by reproductive rights advocates.

For individuals like Gabrielle Goidel, who began her IVF journey coinciding with the ruling, the decision is deeply personal and frustrating. The Goidels are now reconsidering their future in Alabama, underscoring the ruling's immediate and profound impact on families seeking IVF.

This landmark decision by the Alabama supreme court has ignited a critical debate on the intersection of reproductive rights, legal definitions, and the future of IVF, leaving many to navigate a complex and uncertain path forward.


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News: EXTREME IVF

International IVF Initiative 23 January 2024
EXTREME IVF

Tuesday, 30th January (3 pm EST / 8 pm UK / 9 pm CET) 

Moderators:

Jen Barcroft, Lyndon Miles, Staci Lyn Wyatt

Panelists:

Pippa Woolven and Felicity Devey

 Presenters:

" Risky Occupations, tough conditions and Endurance activities" Shaun Rogers

“Gym lifestyle factors and male reproductive health: a study into young adult usage and perceptions” Dr. Meurig T. Gallagher

“Relative Energy Deficiency in sports (RED-S), hormonal disturbances and reproductive issues” Dr. Ifigeneia Giannopoulou

Q and A

View Here


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News: The Link Between Preconception Stress and Pregnancy Blood Sugar: Insights from a Fertility Center Study

IVF.net Newsdesk 23 January 2024

Understanding the Impact of Stress Before Conception on Pregnancy Glucose Levels 
Research Findings from the National Study of Daily Experiences and Other Sources

Recent investigations, including a pivotal study from the Journal of the Endocrine Society, have shed light on the connection between stress prior to conception and elevated blood sugar levels during pregnancy. This correlation suggests significant implications for maternal health, particularly in the realm of glucose regulation and cardiovascular well-being.

Rising Stress Trends: Data from the National Study of Daily Experiences, encompassing 2281 participants, indicates a noticeable increase in stress levels in the 2010s compared to the 1990s. This escalation in stress, further emphasized by a 2020 survey involving 1523 individuals from 48 countries, is likely influenced by factors such as the COVID-19 pandemic.

Gender Differences in Stress: Epidemiological studies reveal that women generally report higher stress levels than men, a trend especially pronounced in those undergoing fertility treatments. This heightened stress in women is critical to note, particularly for those using assisted reproductive technologies, due to its potential impact on metabolic conditions like polycystic ovarian syndrome (PCOS).

Focus on Fertility Treatments: The specific challenges faced by subfertile women, who often experience increased psychological stress, anxiety, depression, and diminished quality of life, highlight the need for focused research. This population is particularly susceptible to gestational diabetes mellitus (GDM) and impaired glucose regulation during pregnancy.

Animal and Human Studies: Research in pregnant animals, such as studies on rats and ewes, demonstrates the effect of stress on glucose metabolism. However, human studies focusing on stress during pregnancy have yielded mixed results.

Lifestyle Factors and Preconception Stress: The period before conception emerges as a critical window for predicting maternal health during pregnancy. Studies indicate that preconception factors like diet, physical activity, and exposure to air pollutants can influence the risk of GDM and other pregnancy-related conditions.

Socioeconomic Factors and Stress: The study also delves into how socioeconomic status might affect the relationship between stress and pregnancy glucose levels. Income and education, for instance, have shown varying associations with stress levels across different demographic groups.

Study Methodology and Results: The study involved 398 women from the Environment and Reproductive Health (EARTH) Study at the Massachusetts General Hospital Fertility Center. It examined preconception stress using the Perceived Stress Scale (PSS-4) and assessed pregnancy glucose levels post a glucose load test. The findings underscore a positive correlation between higher preconception stress and increased pregnancy glucose levels, with variations noted based on the mode of conception and socioeconomic factors.

Implications and Further Research: These insights emphasize the importance of considering preconception stress in relation to cardiovascular health during pregnancy. While the study offers valuable perspectives, its generalizability may be limited, necessitating further research in more diverse populations.

This study not only contributes to our understanding of the relationship between preconception stress and pregnancy glucose levels but also underscores the need for additional research to deepen our knowledge in this area.

Sources

Endocrine Society

https://www.endocrine.org/news-and-advocacy/news-room/2024/women-undergoing-fertility-treatment-who-are-stressed-may-have-heart-health-issues-during-pregnancy

Journal of the Endocrine Society

https://academic.oup.com/jes/article/8/1/bvad152/7499157


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News: Pioneering FDA-Cleared At-Home Intravaginal Insemination for Enhanced Fertility Care

IVF.net Newsdesk 03 January 2024

Mosie Baby, an innovative fertility care provider, recently achieved a significant milestone by obtaining FDA Class II clearance for its at-home intravaginal insemination (IVI) kit. This marks a groundbreaking advancement as the first over-the-counter, FDA-cleared kit designed for IVI, creating new opportunities for patient care in the realm of fertility treatments.

Clinical Implications and Design Designed for use with fresh or cryogenically frozen donor semen, the Mosie Baby Kit includes two uniquely designed syringes and semen collection cups. The syringes feature a patented, barrel-free tip and slit opening, enhancing semen transfer efficiency while minimizing waste. The collection cups, with a proprietary design, optimize semen collection. This kit underwent rigorous clinical and technical testing, including Human Sperm Survival Assay, to ensure non-toxicity, non-irritation, non-sensitization, and freedom from microbial contamination. The kit's design and testing underscore its suitability for at-home use while aligning with clinical standards.

Physician Perspective For physicians, the Mosie Baby Kit presents an option for patients facing infertility challenges or those for whom traditional intercourse is not feasible or preferred. The kit's FDA clearance and adherence to high testing standards provide medical professionals confidence in recommending it as a viable at-home fertility solution. It enables physicians to extend fertility care beyond the clinic, offering a cost-effective, accessible, and user-friendly alternative to in-office procedures. By providing an FDA-reviewed option for at-home insemination, Mosie Baby empowers individuals and couples in their fertility journey, offering them a sense of autonomy and privacy in the process.


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News: ART & Embryology training program

Chennai Fertility Center and Research Institute 02 January 2024
ART & Embryology training program

Training Batch Schedule 2024  

  •                February             =   12th - 26th Feb 2024

The International School of Embryology a unit of Chennai Fertility Centre and Research Institute was established to offer training in Advanced Reproductive Techniques and Embryology for clinicians and embryologists. It will help them to know in-depth knowledge and have good hands-on training. The members of our teaching faculty aim to bring Clinician and Embryologists to the highest level of knowledge about Assisted Reproductive Technology and practical capability.

Our courses cover basics in Andrology, embryology, ICSI, and cryosciences (Hands-on).

Limited Seats. For admission Contact  9003111598 / 8428278218 


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News: ART & Embryology training program

Chennai Fertility Center and Research Institute 07 December 2023
ART & Embryology training program

Training Batch Schedule 2024  

  •                January              =   17th -  31st Jan 2024
  •                February             =   12th - 26th Feb 2024
  •                March                  =   04th - 18th Mar 2024

The International School of Embryology a unit of Chennai Fertility Centre and Research Institute was established to offer training in Advanced Reproductive Techniques and Embryology for clinicians and embryologists. It will help them to know in-depth knowledge and have good hands-on training. The members of our teaching faculty aim to bring Clinician and Embryologists to the highest level of knowledge about Assisted Reproductive Technology and practical capability.

Our courses cover basics in Andrology, embryology, ICSI, and cryosciences (Hands-on).

Limited Seats. For admission Contact  9003111598 / 8428278218 (Whats app)


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News: ART & Embryology training program

Chennai Fertility Center and Research Institute 07 December 2023
ART & Embryology training program

January 2024 Training Batch Schedule - 17th January 2024 - 31st January 2024.

The International School of Embryology a unit of Chennai Fertility Centre and Research Institute was established to offer training in Advanced Reproductive Techniques and Embryology for clinicians and embryologists. It will help them to know in-depth knowledge and have good hands-on training. The members of our teaching faculty aim to bring Clinician and Embryologists to the highest level of knowledge about Assisted Reproductive Technology and practical capability.

Our courses cover basics in Andrology, embryology, ICSI, and cryosciences (Hands-on).

Limited Seats. For admission Contact  9003111598 / 8428278218 (Whats app)


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News: Beyond Conception: Exploring the Link Between Infertility Treatments and Autism Spectrum Disorder

IVF.net Newsdesk 28 November 2023

The research published in JAMA Network Open on the association between infertility and the risk of Autism Spectrum Disorder (ASD) in children provides critical insights into the potential impacts of different modes of conception on child neurodevelopment. This study, conducted in Ontario, Canada, included a substantial cohort of over 1.3 million children and categorized them based on their mode of conception: unassisted, subfertility (infertility without treatment), and assisted reproductive techniques like ovulation induction, intrauterine insemination, in vitro fertilization, or intracytoplasmic sperm injection.

The study found that children born to individuals with infertility had a slightly increased risk of ASD, with the incidence rate of ASD being 1.93 per 1000 person-years in the unassisted conception group. Compared to this group, the adjusted hazard ratios for ASD were 1.20 in the subfertility group, 1.21 following ovulation induction or intrauterine insemination, and 1.16 after in vitro fertilization or intracytoplasmic sperm injection. Notably, obstetrical and neonatal factors appeared to mediate a significant portion of the association between mode of conception and ASD risk. For example, following in vitro fertilization or intracytoplasmic sperm injection, factors like cesarean birth, multifetal pregnancy, preterm birth, and severe neonatal morbidity played a substantial role in mediating the risk of ASD​​​​.

Further insight into the relationship between assisted reproductive technology (ART) and ASD comes from a CDC report examining children born in California between 1997 and 2007. This report found that children conceived using ART were about two times more likely to be diagnosed with ASD compared to children conceived without using ART. The increased risk for ASD in pregnancies conceived with ART was largely due to the higher likelihood of adverse pregnancy and delivery outcomes, like being born as a twin or multiple, being born too early, or being born too small. Additionally, the type of ART procedure impacted the ASD risk, with a higher likelihood of ASD diagnosis in children conceived using intracytoplasmic sperm injection compared to conventional in vitro fertilization. These findings suggest that single embryo transfer, where appropriate, may reduce the risk of ASD among children conceived using ART​​.

Moreover, the CDC report also highlighted that children conceived using ART had a lower median age of autism diagnosis compared to those not conceived with ART. However, despite earlier identification, these children were less likely to have co-occurring intellectual disability or severe deficits in communication and social functioning. The differences in autism diagnosis age and symptom severity were largely accounted for by socio-demographic differences between ART-conceived and non-ART-conceived children. This suggests that earlier identification of autism in children from more advantaged families, who typically have greater access to ART services, contributes to the observed ART-autism association​​.

Overall, these studies underscore the complexity of the relationship between infertility treatments and the risk of ASD in children. They highlight the need for focused care and pregnancy plans for individuals with infertility, both with and without fertility treatment, and emphasize the importance of considering a range of obstetrical and neonatal factors to optimize child neurodevelopment.

Sources: 

JAMA Network Open
Infertility and Risk of Autism Spectrum Disorder in Children

Medical Xpress
Risk for autism increased for children born to those with infertility

Center for Disease Control and Prevention
Key Findings: The association between assisted reproductive technology and autism spectrum disorder

 

 

 


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