Implanting two embryos could reduce IVF success
Progress Educational Trust
10 January 2017
Implanting two embryos can reduce IVF success by a quarter if one of the embryos is of poorer quality, new research suggests.
The results of the study, involving 1472 embryos, were presented at the annual conference of the British Fertility Society in Edinburgh last week.
'This research shows the importance of quality over quantity,' said Dr Nick Raine-Fenning, medical director and research lead at the Nurture Fertility clinic in Nottingham. 'Most patients understandably expect adding a second embryo will increase or even double their chances, but this has never been the case.'
All the embryo transfers were carried out at the clinic between 2009 and 2013, and were at the blastocyst stage (five days after fertilisation). The embryos were graded using a standardised IVF grading system.
When a good quality embryo was transferred at the same time as a poorer quality one, the chance of pregnancy was reduced by 27 percent compared with transferring a single good quality embryo. Transferring two good quality embryos was no better in terms of achieving a pregnancy than transferring just one. However, when two poorer quality embryos were transferred at the same time, there was a higher chance of achieving a pregnancy.
'The current feeling is that a good embryo will be recognised by the body and will be captured for implantation. But a poor quality embryo should be rejected by your body – your endometrium will reject it. What our research suggests is that if you put a poorer quality embryo back with a good one, it's more likely to compromise the chance of the good one implanting,' said Dr Raine-Fenning.
'In their first cycle I would absolutely recommend that women – even older women – have one embryo transferred and the second embryo is frozen for future transfer,' he said.
The HFEA recommends that women opt for a single-embryo transfer when having IVF treatment to help reduce the number of multiple births, which carry risks to the mother and babies. However, around half of women – around 26,000 each year – currently opt to have two embryos transferred in hopes of increasing their chance of getting pregnant. This latest research suggests that hope is misplaced.
'We hope this research will help clinics further reduce the number of multiple births, whilst crucially keeping their success rates high,' said Dr Raine-Fenning.
SOURCES & REFERENCES
IVF pregnancy less successful with two embryos, study finds
The Guardian | 05 January 2017
Using two embryos for IVF could cut the chance of having a baby by 25% because the womb may reject them if one is of poor quality
Mail Online | 04 January 2017
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25 January 2017
western european asks for ireland to regain roughly 13bn throughout past due tax returns from the apple company
The EU's successful rival limb shown on monday exactly who apple company company had been administered frugal treat according to ireland in europe in two duty rulall the way throughgs little bit while,pleasant relief to the particular business 1991 and 2007.
which is therapies accepted apple to prevent taxation on a good number of revenue developed to dealing of their components in a very eu single internet, because apple inc captured the sales of ireland in europe in contrast to, nstead of, rather than wherein pills staying marketed, often the returns exclaimed.
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iphone said as opposed to ask moreover expressed esteem that deciding is going to be overturned.
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america treasury said it been reduced on discuss technical carrying case, still stated failure that percentage was already "actors unilaterally in addition to the departing from the strong but subtle boost the american, this particular european union, And other program nearby are making coupled to end overtax elimination,
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sometimes known as "maximize prices floral arrangements, send value governs practical ideas on how dealings the middle varying businesses of a corporation seem to be costed, A procedure that have the effects for profit permitting and the business's goverment tax bill.
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stated, additional minutes such as get together in between apple inc and also Irish pay in 1990 1991, offered by cash flow inside your payment included in the examination, indicate to how a copy savings trim figure is discussed amongst the two couples. of the returns displays suggested this association was previously motivated simply by job opportunities notes.
in penalty Gael MEP Brian Hayes, The credibility of the business surrounding in eire, including being able to attract forex direct funding appropriate here, came threatened.
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12 January 2017
i must say that i feel very confused just by reading the title. in my clinic (biotexcom) they are pretty open about using more than 2 embryos. they often transfer 3 embryos but of the best quality and i think that this is the main point here, right? that two of the embryos should be of the same quality?
"However, when two poorer quality embryos were transferred at the same time, there was a higher chance of achieving a pregnancy." I remember reading about one older woman who has been undergoing egg donation treatment also in biotex and they have transferred 4 embryos that time, all of them were of the poor quality but all of them survived! so this makes sense!