Homepage  /  News

Environmental chemicals affect sperm epigenetics

Dr Kimberley Bryon-Dodd

Progress Educational Trust

25 September 2017

| | | |
[BioNews, London]

A type of chemical found in various personal beauty products and plastics may affect sperm and lower reproductive success, according to a new study.

Researchers have linked significant amounts of phthalates in male urine samples with epigenetic changes in the DNA of the subjects' sperm.

'There has always been this heavy concern in the past with expectant mums not smoking and not drinking, for example, to protect the fetus,' said lead author Dr Richard Pilsner of the University of Massachusetts Amherst, USA. 'In this study, we see that dad's environmental health contributes to reproductive success.'

Phthalates, used in products ranging from shaving cream to food packaging, are estimated to be detectable in nearly 100 percent of the US population. They have been associated with lower sperm concentration and movement, and increased sperm cell DNA damage and death.

The small study examined the urine of 48 men from couples attending the IVF clinic at Baystate Medical Centre, Massachusetts for eight different phthalate concentrations. They also analysed DNA extracted from sperm, taken on the same day, for epigenetic changes in regions of the genome.

Semen samples from men with higher urinary concentrations of phthalate metabolites were associated with a methylation on 131 regions of sperm DNA. The researchers found many of these regions affected the function of genes related to growth, development and 'basic cellular function', and some were also associated with poorer quality of blastocysts.

Dr Pilsner said: 'For sperm to mature is a 72-day process, almost three months, and our study shows that this preconception time-period may represent an important developmental window by which environmental exposures may influence sperm epigenetics, and in turn, early life development. So in the same way mum needs to be careful, dad also needs to.'

Coming from a small study, the findings need to be replicated and confirmed on a larger scale. Additionally as all of the men were recruited from an IVF clinic, the findings may not apply to the wider population.

Professor Allan Pacey of the University of Sheffield in the UK said the small study should be interpreted with caution, as 'the results only describe an association and not cause and effect'.

'Therefore, men currently undergoing IVF with their partners should not panic as it is very difficult to make any firm conclusions from this data. However, they should concentrate on being as healthy as possible by not smoking cigarettes (a much bigger epigenetic hazard in my view) and eating a sensible diet, with five portions of fruit and vegetables per day (paternal diet has been implicated as important in sperm DNA methylation).'

The study was published in Human Reproduction.

SOURCES & REFERENCES

A study found that chemicals in shaving cream could be altering men's sperm

National Post | 12 September 2017
 

Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study

Human Reproduction | 12 September 2017
 

Study suggests father's environmental exposure affects sperm epigenetics

Medical Xpress | 12 September 2017
 

UMass Research Tells Dads-To-Be To Avoid Plastic Wrap, Mac & Cheese, Cologne

New England Public Radio | 12 September 2017
 



http://www.BioNews.org.uk
© Copyright Progress Educational Trust

Reproduced with permission from BioNews, an email and online sources of news, information and comment on assisted reproduction and genetics.

Share IVF News on FaceBook   Share IVF News on Google+   Share IVF News on Twitter

Page Views: 947
Add to Favorites | Reply to Ad | Tell Your Friends
Date Added: 25 September 2017   Date Updated: 25 September 2017
Customer Reviews (0)
write a review
(No reviews found. You may write the first one!)


Join Our Newsletter - Don't Miss Anything!!!

Stay in touch with the latest news by subscribing to our regular email newsletters