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Comprehensive assessment of cryogenic storage risk and quality management concerns: best practice guidelines for ART labs

Journal of Assisted Reproduction and Genetics

19 December 2018

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M. C. Schiewe & M. Freeman & J. B. Whitney & M. D. VerMilyea & A. Jones & M. Aguirre & C. Leisinger &G. Adaniya & N. Synder & R. Chilton & E. J. Behnke


Recent publicized events of cryogenic storage tank failures have created nationwide concern among infertility patients and patients storing embryos and gametes for future use. To assure patient confidence, quality management (QM) plans applied by in vitro fertilization (IVF) laboratories need to include a more comprehensive focus on the cryostorage of reproductive specimens. The purpose of this review is to provide best practice guidelines for the cryogenic storage of sperm, oocytes, embryos, and other reproductive tissues (e.g., testicular and ovarian tissue, cord blood cells, and stem cells) and recommend a strategy of thorough and appropriate quality and risk management procedures aimed to alleviate or minimize the consequences from catastrophic events.



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Date Added: 19 December 2018   Date Updated: 19 December 2018
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