The Curious Case of Lactate, a Blastocyst and an Endometrium
Professor David Gardner, 19 July 2023 Lactate is typically considered a “waste-product” of glucose metabolism, produced through glycolysis, when there is insufficient oxygen available. But why does the blastocyst produce significant quantities of lactate even when there is an abundance of oxygen? The answer to this question will make you rethink completely the significance of metabolic functions, and you will discover that this quirky metabolic trait is a prerequisite for a tissue that needs to invade, establish a blood supply and avoid immuno rejection. Spoiler alert – cancers use the same trick as our beautiful blastocysts to invade surrounding tissues! PROFESSOR DAVID K. GARDNER, FAADavid is the Scientific Director of Melbourne IVF and a Distinguished Professor in the School of BioSciences, University of Melbourne. This video is one of many educational resources produced by the International IVF Initiative (I3). As a worldwide movement, I3 focuses on improving education and refining methods in assisted reproductive technologies. To explore a wider range of educational content, we invite you to visit https://ivfmeeting.com. |
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